Neuron· Zohaib N. Khan, Cristina C. Clement, Paula Roßmüller, Salli Antila, Lincoln Sutherland, Rafi Kabarriti, Justina Shafik, Igor Smirnov, Angelo D’Alessandro, Monika Dzieciatkowska, Barbara Roda, Valentina Marassi, Wanxia Li Tsai, Massimo Gadina, Allen Tannenbaum, Markku Varjosalo, Salla Keskitalo, András Piffkó, Sunil Koundal, Zachary Gursky, Ralph R. Weichselbaum, Michael B. Prystowsky, Thomas J. Ow, Silvia Formenti, Christian Sorg, Benedikt Zott, Kari Alitalo, Helene Benveniste, Jonathan Kipnis, Laura Santambrogio·· 2026-09-29AI 评分29
颈淋巴结清扫术损害脑淋巴清除与突触蛋白稳态
Cervical lymphadenectomy impairs brain lymphatic clearance and synaptic proteostasis
AI 导读
Khan、Clement 等人发现，接受颈部淋巴结切除的受试者认知障碍风险升高。脑淋巴清除受阻会引发代谢与氧化应激，进而促成神经元损伤。这些发现揭示了代谢废物清除受损与认知障碍之间的关联。
摘要
Khan, Clement et al. show that subjects undergoing removal of cervical lymph nodes presented an elevated risk for cognitive impairment. The disruption of brain lymphatic clearance triggers metabolic and oxidative stress, which is conducive to neuronal damage. These findings reveal a connection between impaired metabolic waste disposal and cognitive impairment.
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来源：Neuron · cell.com