Neuron· Pingping Zhao, Xing Chen, Arash Bellafard, Avaneesh Murugesan, Jonathan Quan, Daniel Aharoni, Peyman Golshani·· 2026-09-10AI 评分62
小鼠自闭症模型中伏隔核社会表征出现细胞类型特异性紊乱
Cell-type-specific disruption of nucleus accumbens social representations in a mouse model of autism
AI 导读
Zhao 等在小鼠自闭症模型中报告，社会信息在伏隔核中存在表征，且该表征变得不稳定。研究进一步区分了 D1 与 D2 中型棘状神经元对社会行为的不同贡献，并显示靶向这些环路可改善社交缺陷。依据期刊摘要，上述结果来自小鼠模型，涉及的是动物行为与环路层面，是否适用于人类自闭症仍需进一步研究。
摘要
Zhao et al. show that social information is represented in the nucleus accumbens and becomes unstable in a mouse model of autism. They further identify distinct contributions of D1- and D2-medium spiny neurons to social behavior and show that targeting these circuits can ameliorate social deficits.
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来源：Neuron · cell.com