Neuron· Haiyan Sun, Xin Liu, Xu Zhao, Yanqin Zhou, Han Sun, Jiayi Zhang, Yan Li, Jun-Li Cao, Shuming An·· 14 天前AI 评分72
小鼠研究：恢复睡眠经未定带神经元群及不同环路产生镇痛
Recovery sleep induces analgesia via sleep ensembles of the zona incerta acting through distinct neural circuits in mice
AI 导读
Haiyan Sun、Liu 等人在小鼠中识别出被睡眠激活的未定带（zona incerta）神经元群，该神经元群参与 NREM 睡眠与镇痛。依据摘要，慢性疼痛会抑制这些神经元，而激活它们可促进 NREM 睡眠并缓解疼痛；其投射到外侧下丘脑与后丘脑的两条通路分别调控睡眠与伤害感受。该结果为睡眠与疼痛交互提供环路层面的候选机制，但属小鼠研究，是否适用于人类仍需验证。
摘要
Haiyan Sun and Liu et al. identify sleep-activated zona incerta neuronal ensembles mediating NREM sleep and analgesia. Chronic pain suppresses these neurons, whereas their activation promotes NREM sleep and alleviates pain. Their divergent projections to the lateral hypothalamus and posterior thalamus separately control sleep and nociception.
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来源：Neuron · cell.com