Neuron· Fergil Mills, Christopher R. Lee, James R. Howe, Hao Li, Maria N. Keisler, Shan Shao, Felix H. Taschbach, Mackenzie E. Lemieux, Faith Aloboudi, Jesse White, May G. Chan, Matilde Borio, Laurel R. Keyes, Hannah S. Chen, Fabiha Bushra, Gates P. Schneider, Dani P. Lemmon, Kyung J. Lee, Alexa L. Gross, Kanha Batra, Reesha R. Patel, Meenakshi M. Asokan, Jeremy Delahanty, Christian Cazares, Christopher R. Heyman, Nicholas B. Poll, Liezl Maree, Romy Wichmann, Talmo D. Pereira, Marcus K. Benna, Cory M. Root, Kay M. Tye·· 2026-09-14AI 评分68
杏仁核-纹状体过渡区神经元编码持续线索反应并引导防御行为
Amygdalostriatal transition zone neurons encode sustained cue responses to guide defensive behaviors
AI 导读
依据摘要，研究将杏仁核-纹状体过渡区（ASt）鉴定为一个遗传上可区分的区域，并报告其在条件性恐惧反应中具有此前未被充分认识的作用。ASt 神经元对预示电击的线索表现出持续反应，且对防御行为的表达既必要又充分。该结果基于动物研究，是否适用于人类仍需进一步验证；摘要未提供样本量、具体实验设计与统计结果。
摘要
We identify the amygdalostriatal transition zone (ASt) as a genetically distinct region that plays a previously unappreciated role in conditioned fear responses. We find that ASt neurons show sustained responses to shock-predictive cues and are both necessary and sufficient for the expression of defensive behaviors.
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来源：Neuron · cell.com