油莎草饮食对鱼藤酮诱导帕金森样模型大鼠海马的影响：一项初步研究

Parkinson disease is a progressive neurodegenerative disorder contributing to cognitive decline and memory impairment beyond its characteristic motor deficits. Rotenone, a mitochondrial complex I inhibitor, reliably reproduces both the motor and non-motor features of Parkinson disease in experimental models. Tiger nut (Cyperus esculentus) is a commonly consumed plant known for its antioxidant and anti-inflammatory properties; however, its neuroprotective efficacy against rotenone-induced hippocampal damage is not yet fully elucidated. This study, therefore, evaluated the neuroprotective efficacy of tiger nut-infused diet on the hippocampus in a rotenone-induced Parkinson disease model using male Wistar rats. Thirty-two male Wistar rats weighing between 100 g to 150 g were obtained from the Animal Holding facility of Babcock University, Ilishan-Remo, Ogun State. The rats were randomly assigned into four groups (A, B, C and D) (n = 8). Group A served as the control and received normal rat chow and sunflower oil. Group B received tiger nut-infused diet only. Group C received rotenone (2 mg/kg) intraperitoneally. Group D received rotenone (2 mg/kg) concurrently with tiger nut-infused diet for 28 days. Neurobehavioral assessments were conducted using the open field test and Y-maze tests. Oxidative stress biomarkers, including malondialdehyde, catalase, and glutathione, were assayed from hippocampal homogenates, and gamma-aminobutyric acid was measured as a neurotransmitter parameter. Histological evaluation was performed using hematoxylin and eosin for general cytoarchitecture, Cresyl Fast Violet for Nissl substance integrity, and Luxol Fast Blue for myelin visualization. Data were analyzed using One-way ANOVA followed by the Student Newman-Keuls post-hoc test on GraphPad Prism 9.0, with significance set at p [≤] 0.05. Rotenone administration produced significant impairments in locomotor activity and spatial working memory, reduced catalase activity, and caused marked

中文翻译还没有生成，先显示原文。