Neuron· Hailan Liu, Qingzhuo Liu, Jonathan C. Bean, Fuhui Wang, Jinjing Jian, Yongxiang Li, Kristine M. Conde, Mengjie Wang, Yue Deng, Yuxue Yang, Tong Zhou, Jingjing Cheng, Yutian Liu, Meixin Sun, Xinming Liu, Jiamin Qiu, Xi Wu, Lamei Xue, Qingchun Tong, Benjamin R. Arenkiel, Mingshan Xue, Huxing Cui, Tzu-Chiao Lu, Yanyan Qi, Hongjie Li, Chunmei Wang, Yang He, Yongjie Yang, Longlong Tu, Yong Xu·· 2026-09-25AI 评分72
Neuron：下丘脑 Lef1+ 神经元群协调寒冷下的代谢适应
A hypothalamic neuronal population coordinates metabolic adaptations to cold
AI 导读
依据期刊摘要，Liu 等人鉴定出一群下丘脑 Lef1+ 神经元，协调寒冷环境下的摄食与产热适应。摘要称寒冷抑制 Kcnk2/TREK-1 的功能，从而增强神经元活动，提示一条把环境温度与神经及代谢反应联系起来的分子机制。该结果来自动物研究，具体样本量、实验设计与统计结果未在摘要中报告，是否适用于人类尚需进一步研究。
摘要
Liu et al. identify a population of Lef1+ hypothalamic neurons that coordinates feeding and thermogenic adaptations to cold. Cold suppresses Kcnk2/TREK-1 function to enhance neuronal activity, revealing a molecular mechanism linking environmental temperature to neural and metabolic responses.
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来源：Neuron · cell.com