Neuron· Shuimu Jin, Yingxiang Liu, Tianqi Wang, Xiaoxiao Shan, Jingmin Liu, Siyi Zhu, Tong Shen, Yilan Liang, Guo Wei, Yijing Cao, Xia Li, Shumin Duan, Hailan Hu, Zhengxiao Fan·· 2026-08-12AI 评分60
Jin 等建立 win maze 范式：中皮层通路调控小鼠胜负后的竞争参与
Status-dependent competition engagement via mesocortical pathway
AI 导读
Jin 等建立 win maze 范式，研究小鼠在获胜后如何决定是否再次参与竞争。依据摘要，优势雄性表现出更强的竞争参与，dmPFC 神经动态可预测其后续选择，中皮层多巴胺对参与行为具有双向调控作用。该结果为竞争动机的神经环路机制提供了动物实验证据，但材料仅为摘要，样本量、统计结果与实验细节未报告，向人类外推仍需进一步研究。
摘要
Jin et al. establish the win maze to study how mice decide to re-engage in competition after winning outcomes. They show that dominant males display stronger competition engagement, with dmPFC neural dynamics predicting future choices and mesocortical dopamine bidirectionally regulating engagement.
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来源：Neuron · cell.com