Neuron· Hye Ji J. Kim, Luke T. Geiger, Julie-Anne Balouek, Lisa Z. Fang, Mason R. Barrett, Jeremy M. Thompson, Lorna A. Farrelly, Travis Hage, Rixing Lin, Andy S. Chen, Megan Tang, Hao Huang, Anna Buretta, Agatha Chan, Shannon N. Bennett, Benjamin A. Garcia, Ian Maze, Meaghan C. Creed, Catherine Jensen Peña·· 2026-08-07AI 评分62
早期生活应激改变腹侧被盖区 H3K4me1，启动应激敏感性
Early-life stress alters H3K4me1 in VTA to prime stress sensitivity
AI 导读
Kim、Geiger 等报告，早期生活应激会提高腹侧被盖区（VTA）的染色质修饰 H3K4me1 及其书写酶 SETD7 的水平。依据摘要，这种表观遗传“启动”对早期生活应激敏化后续应激的转录、生理和行为反应既是必要的也是充分的。该结果提示 VTA 的表观遗传状态可能参与塑造个体后续的应激反应，但材料仅为摘要，样本量、统计结果与实验设计细节未报告，且研究结论来自动物模型，能否外推到人类仍需验证。
摘要
Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic priming is necessary and sufficient for early-life stress to sensitize transcriptional, physiological, and behavioral responses to subsequent stressors.
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来源：Neuron · cell.com