童年虐待与发育中的大脑：迈向个体化的精神疾病风险模型
Childhood maltreatment and the developing brain: toward individualized models of psychiatric risk
一篇发表于 Trends in Cognitive Sciences 的观点文章提出，童年虐待对大脑发育的影响随逆境类型、发育时间窗和遗传易感性而不同，而常规方法难以刻画这种异质性。作者认为，规范建模、多变量方法和多基因风险评分可提供互补框架，用于解析这种变异并推进机制理解与临床分层。依据摘要，该文为框架性论述，未报告具体样本、效应量或验证结果，其临床分层价值仍待实证检验。
Childhood maltreatment shapes brain development in ways that vary by adversity type, developmental timing, and genetic vulnerability to psychiatric illness—a heterogeneity that conventional approaches capture poorly. We contend that normative modeling, multivariate methods, and polygenic risk scores offer complementary frameworks for parsing this variability and advancing mechanistic insights and clinical stratification.
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来源：Trends in Cognitive Sciences · cell.com