PNAS· Mathieu SchulzXiaojian ShaoRomain LambrotChristine LafleurDonovan ChanMarie-Charlotte DumargneAmanda J. MacFarlaneSergey MoskovtsevGuillaume BourqueTomi PastinenClifford LibrachHope WeilerJacquetta TraslerSarah Kimminsahttps://ror.org/0161xgx34Department of Pathology and Cell Biology, University of Montreal Hospital Research Center, Montreal, QC H2X 0A9, Canadabhttps://ror.org/04mte1k06Digital Technologies Research Center, National Research Council of Canada, Ottawa, ON K1A 0R6, Canadachttps://ror.org/03c4mmv16Ottawa Institute of Systems Biology, Department of Biochemistry Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canadadhttps://ror.org/04pemf943Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canadaehttps://ror.org/035b05819Center for Basic Metabolic Research, University of Copenhagen, Copenhagen DK-2200, Denmarkfhttps://ror.org/05p8nb362Nutrition Research Division, Health Canada, Ottawa, Ottawa, ON K1A 0K9, CanadagCReATe Fertility Clinic Center, Toronto, ON M5G 1N8, Canadahhttps://ror.org/03dbr7087Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canadaihttps://ror.org/01pxwe438McGill Genome Center, Department of Human Genetics, McGill University, Montreal, QC H3A 0G1, Canadajhttps://ror.org/04zfmcq84Genomic medicine Center, Children’s Mercy Hospital, Kansas City, MO 64108khttps://ror.org/03dbr7087Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON M5G 1E2, Canadalhttps://ror.org/05p8nb362Nutrition Research Division, Bureau of Nutritional Sciences, Food and Nutrition Directorate, Health Products and Food Branch, Health Canada, Ottawa K1A 0K9, Canadamhttps://ror.org/04pemf943Departments of Pediatrics, Human Genetics, Pharmacology and Therapeutics, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC H4A 3J1, Canadanhttps://ror.org/01pxwe438Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada·· 12 天前
精子DNA甲基化改变为超重和年长男性向代际疾病传播提供表观遗传途径
Altered sperm DNA methylation provides an epigenetic route from overweight and older men to intergenerational disease transmission
AI 导读
超重和年长男性的精子DNA甲基化改变，可能构成代际疾病传播的表观遗传途径。
摘要 · AI 翻译
《美国国家科学院院刊》，第123卷，第42期，2026年10月。意义：谈到妊娠与孩子的健康，母亲长期以来一直是关注焦点。然而，来自动物模型的不断积累的证据表明，父亲的健康状况与暴露同样重要。对于人类而言，目前仍……
中文由 AI 翻译，仅供参考，以原文为准。
来源：PNAS · pnas.org