Neuron· Zachary B. Hobel, Taryn R. Brechbill, Adelis M. Cruz, Lu-Tang Yang, Kimberly Jimenez, Brandon Wu, Qinlin Liu, Sasha B. Kirsch, Nicole J. Fernandes, Roland Bock, Veronica A. Alvarez, Kim T. Blackwell, Joshua L. Plotkin·· 2026-09-25AI 评分67
基底外侧杏仁核至背外侧纹状体投射可调节刺激诱发的运动行为
A basolateral amygdala to dorsolateral striatum projection modulates stimulus-evoked motor behavior
AI 导读
依据 Neuron 期刊摘要，Hobel 等人报告小鼠基底外侧杏仁核到背外侧纹状体存在一条直接、功能性投射。该稀疏通路可调节背外侧纹状体活动，延长并增强感觉诱发的运动反应，并在 Sapap3 缺失的强迫症小鼠模型中活动过强。作者据此提出一条边缘系统调节感觉运动行为的通路；结果来自动物模型，是否适用于人类仍需进一步研究。
摘要
Hobel et al. describe a direct, functional projection from the basolateral amygdala to dorsolateral striatum. This sparse pathway modulates dorsolateral striatal activity, can prolong and augment sensory-evoked motor responses, and is overactive in a Sapap3 null mouse model of OCD, providing a route for limbic modulation of sensorimotor behavior.
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来源：Neuron · cell.com